Inhibition of Wb-iPGM using analogues of Clorsulon and co-administration with DEC for bancroftian filariasis treatment

Wucherria bancrofti (Wb) is the main causative agent of Filariasis. Lymphatic Filariasis (LF) is a disabling, disfiguring, and a poverty promoting disease which is caused by the parasitic filarial nematode worms. The identification of essential nematode genes has shown that independent phosphoglycerate mutase (iPGM) is an excellent drug target against parasitic nematodes. In this current study, we have used our previously modeled structure of Wb-iPGM to inhibit the Embden Mayerhoff pathways of Wb using the Clorsulon and their analogues. Further, these analogues were scrutinized based on the pharmacokinetics and best complex were proposed to inhibit the Wb-iPGM enzyme. This current study provides an insight towards the process of design and development of novel drug target and their mode of interaction with the potent anthelmintic drugs.